Remote sensing change detection has achieved amazing results in recent years, especially the application of convolutional neural networks (CNN) and Transformer networks, which have revolutionized the field.However, the complex ground cover changes and the differences in lighting conditions caused by different times still pose challenges to the dete
Abstract HIV-1 Nef is an important pathogenic factor for HIV/AIDS pathogenesis.Studies have shown that the association of Nef with the Vegetable / Fruit Cutters inner leaflet of the plasma membrane and with endocytic and perinuclear vesicles is essential for most activities of Nef.Using purified recombinant proteins in pull-down assays and by co-im
The recently discovered Nesfatin-1 plays a role in appetite regulation as a satiety factor through hypothalamic leptin-independent mechanisms.Nesfatin-1 is co-expressed with Melanin-Concentrating Hormone (MCH) in neurons from the tuberal hypothalamic area (THA) which are recruited during sleep states, especially paradoxical sleep (PS).To help decip
Waxing/waning of the ice sheets and the associated change in thermohaline circulation have played an important role in global climate change since major continental ice sheets appeared in the northern hemisphere about 2.75 million years ago.In the earliest glacial stages, however, establishment of the linkage between ice sheet development and ocean
ABSTRACT: Objectives: Isolation of colistin- and carbapenem-resistant Klebsiella pneumoniae (CCR-Kp) is increasing in hospital settings worldwide, which is related to increased morbidity, mortality and healthcare costs.The aim of this work was to perform whole-genome sequencing (WGS), genomic and phylogenetic analysis, and conjugation assays of an